Abstract
The occurrence of acute respiratory distress syndrome (ARDS) as a result of a tricyclic antidepressant (TCA) overdose is rarely reported, but is of greater interest because of its association with TCA overdose and its reproducibility in animal models. We reported a 43-year-old female who ingested a large amount of imipramine in an attempted suicide. She developed deep coma and hypotension, but did not have cardiac dysrhythmia or seizure. ARDS developed 15 hours later and was treated with extracorporeal membrane oxygenation (ECMO). After a prolonged hospital stay, she was finally discharged uneventfully with moderate restrictive lung disease. We recommended a consideration of the use of ECMO in cases of severe ARDS caused by TCA.
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