Imino‐Fluoroalkanesulfonylation of γ,δ‐Unsaturated Oxime Esters Enabled by Photoredox/Cu Dual Catalysis

Abstract

AbstractSulfonyl‐tethered N‐containing heterocycles are valuable building blocks in synthetic and pharmaceutical chemistry. Recently, the installation of fluoroalkanesulfonyl groups into heterocycles via the difunctionalization of alkenes still remains challenging. Herein in this work, an imino‐fluoroalkanesulfonylation of γ,δ‐unsaturated oxime esters has been achieved via photoredox/Cu dual catalysis. A variety of fluoroalkanesulfonyl‐tethered pyrroline derivatives have been readily synthesized in moderate to good yields under mild conditions.