Abstract
Imidazoline receptors (29/30- and 45-kDa proteins) were quantitated in postmortem brains of patients with Alzheimer's disease (AD) by using immunoblotting techniques and a specific antiserum. Increased levels of the 29/30-kDa protein (30%), 45-kDa protein (36%) and glial fibrillary acidic protein (88%) were found in the frontal cortex of AD patients. These findings are in line with the reported higher density of imidazoline receptors labelled by [ 3H]idazoxan in AD brains, suggesting that these imidazoline receptor proteins are related to the I 2-imidazoline receptor located in mitochondria of glial (astrocyte) cells.
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