Abstract
The present study, deals with the synthesis of 2-substituted-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazoles from 2-amino-5-substituted-1,3,4-thiadiazoles and 2-bromo-1-phenylethanone, which was carried out applying a microwave-assisted aqueous procedure. Furthermore, the gas-phase thermal behaviour of these imidazothiadiazoles in flash vacuum pyrolysis reactions has been studied. It has been shown that thermolysis conditions induce thiadiazole fragmentation to give indole-carbonitriles and other nitriles. The quantum chemical calculations support a stepwise mechanism for the fragmentation of imidazothiadiazoles to afford products.
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