Abstract
IMGT®, the international ImMunoGeneTics information system®(http://www.imgt.org) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) and proteins of the IgSF and MhSF superfamilies. IMGT® is built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences and 3D structures. The concepts include the IMGT® standardized keywords (identification), IMGT® standardized labels (description), IMGT® standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation). IMGT® comprises 7 databases, 17 online tools and 15 000 pages of web resources, and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data. Tools and databases are used in basic, veterinary and medical research, in clinical applications (mutation analysis in leukemia and lymphoma) and in antibody engineering and humanization. The IMGT/mAb-DB interface was developed for therapeutic antibodies and fusion proteins for immunological applications (FPIA). IMGT® is freely available at http://www.imgt.org.
Highlights
IMGT R, the international ImMunoGeneTics information system R [1], was created in 1989 by Marie-Paule Lefranc at Montpellier, France (Universitede Montpellier and Centre National de la Recherche Scientifique (CNRS))
The founding of IMGT R marked the advent of immunoinformatics, a new science, which emerged at the interface between immunogenetics and bioinformatics [2]
IMGT R is specialized in the other proteins of the immunoglobulin superfamily (IgSF) and major histocompatibility (MH) superfamily (MhSF) and related proteins of the immune system (RPI) of vertebrates and invertebrates [1]
Summary
IMGT R , the international ImMunoGeneTics information system R (http://www.imgt.org) [1], was created in 1989 by Marie-Paule Lefranc at Montpellier, France (Universitede Montpellier and CNRS). The IMGT unique numbering and IMGT Collier de Perles provide a definitive and universal system across species including invertebrates, for the sequences and structures of the V, C and G domains of IG, TR and MH, and more generally of the IgSF and MhSF superfamilies [57]. This tool run against the IMGT/DomainSeq reference directory database (Table 1) that include sets for the V, C and G domains.
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