Abstract
UV-exposure induces photoaging of the skin. Testing the efficacy and safety of oral Imedeen in photoaged skin. Three month placebo-controlled randomized study of 144 subjects and 9-month-uncontrolled continuation. Efficacy measurements included clinical evaluation, self-evaluation, photograph evaluation, as well as ultrasound, transepidermal water loss and replica measurements. After 3 months, no significant effects were detected. One years treatment gave significant improvement compared with baseline in investigator's evaluation of fine lines and overall photoaging, in photograph evaluation of fine lines, overall photoaging, telangiectasia and hyperpigmentation, in self-evaluation of skin condition, density measurements by ultrasound, trans-epidermal water loss and skin smoothness from analysis of skin replica. No serious side-effects related to treatment were reported. Imedeen appears effective and safe for treatment of photoaged skin.
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