Abstract
AimsCardiac dysfunction after CPR has been proved to be one of the most important reasons for the death in the early period of successful cardiopulmonary resuscitation (CPR). Matrix metalloproteinases (MMPs)...
Highlights
This study aimed to determine whether (a) there was an imbalance between matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) after cardiopulmonary resuscitation (CPR) in a canine model of prolonged ventricular fibrillation (VF); (b) with the duration of VF, the degree of the imbalance would be greater; and (c) there was a relationship between the level of Matrix metalloproteinases (MMPs)-9 or tissue inhibitors of metalloproteinase (TIMPs)-1 and the cardiac function
TIMP-1 and MMP-9 were analysed by Western blot and immunohistochemistry
The level of MMP-9 did not achieve statistical significance in the three groups (p>0.05), they were higher in VF and longer-duration VF groups
Summary
Heart October 2011 Vol 97 No 21 Suppl 3 [gw22-e0156] IMBALANCE BETWEEN TISSUE INHIBITOR OF METALLOPROTEINASE-1 AND MATRIX METALLOPROTEINASE-9 AFTER CARDIOPULMONARY RESUSCITATION Aims Cardiac dysfunction after CPR has been proved to be one of the most important reasons for the death in the early period of successful cardiopulmonary resuscitation (CPR).
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