Abstract
Myopia is one of the commonest eye pathologies that could affect 2.56 billion people by 2020. Today high myopia is a leading cause of blindness worldwide due to associated ocular illness. Nevertheless, the cellular bases for these diseases to develop are unclear in many areas. We conducted a prospective study of oxidative stress and growth factors in human myopic and non myopic eyes in an attempt to increase our understanding of the underlying physiopathological conditions to adequately early diagnose, prevent and treat the retina problem that derives from myopia. Aqueous humor samples were obtained from 41 patients being operated for cataracts in our hospital. Axial length, refractive status and complete ophthalmologic examination were recorded. The VEGF and HGF levels were determined by an ELISA kit. Total antioxidant capacity and total nitrites/nitrate levels were established with a lab kit. We show for the first time an increase in the total nitrite levels in high myopia. We also propose for the first time the concurrence of three factors: myopia, oxidative stress, and oxidative stress together with growth factors in the same group of patients. In this way, it would not be accurate to envision high myopia as a type of normal myopia, but one with more diopters or longer axial length.
Highlights
Human myopia is one of the most common eye disorders of significant world public health concern (Young, 2009)
No significant differences were observed between the C (420.1 ± 117.5 pg/ml) and low myopia (LM) (496.9 ± 158.3 pg/ml) groups (p > 0.05)
The levels in the LM patients (132.1 ± 36.6 pg/ml) were lower, but no significant differences were found with the C group (p > 0.05)
Summary
Human myopia is one of the most common eye disorders of significant world public health concern (Young, 2009). Visual impairment associated with myopic macular degeneration will grow to reach 55.7 million people (Fricke et al, 2018). In Europe, myopia prevalence is about 24.3% with an age-standardized prevalence of 30.6% (Williams et al, 2015). The increase in myopia prevalence is even more marked in young European adults, with a prevalence of 47.2% (Williams et al, 2015). Myopia is one of the main causes of visual impairment, together with macular degeneration, glaucoma, macular hemorrhage and cataracts (Saw et al, 2005). For all these conditions, oxidative stress has been observed to play a relevant role (BoschMorell et al, 2015). Genetic and environmental factors have been associated with this disease (Lin et al, 2009; Wojciechowski, 2011)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
