Imatinib Pharmacokinetics in a Large Observational Cohort of Gastrointestinal Stromal Tumour Patients.

Abstract

Low trough imatinib concentration (C min) values have been associated with poor clinical outcomes in gastrointestinal stromal tumour (GIST) patients. This study describes the pharmacokinetics of imatinib in a large cohort of GIST patients in routine clinical care. An observational study was performed in imatinib-treated GIST patients. Patient and tumour characteristics were derived from the Dutch GIST Registry and medical records. Imatinib concentrations were measured by liquid chromatography with tandem mass spectrometry. The analyses included the occurrence of a low imatinib C min (<1000µg/L), the change in the C min over time and the correlation between exposure and response. In total, 421 plasma samples were available from 108 GIST patients. Most patients (79.6%) received an imatinib dose of 400mg. The inter- and intrapatient variabilities in C min were 54 and 23%, respectively. In the first steady-state sample, 44.4% of patients presented with C min values<1000µg/L; 32.4% of patients had values<1000µg/L in >75% of their samples. Only 33.3% of patients had C min values ≥1000µg/L in all measured samples. No decrease in C min over time was found (P>0.05). Fifty-seven (91.9%) of 62 palliative-treated patients had a tumour response (median C min 1271µg/L). Five palliative patients (8.1%) did not respond (median C min 920µg/L). Given the limited number of non-responders in this cohort, no statistically significant association with clinical benefit could be demonstrated. In routine clinical care, one third of GIST patients are systematically underexposed with a fixed dose of imatinib. Prospective clinical studies are needed to investigate the value of C min-guided imatinib dosing in GIST patients.