Abstract
10012 Background: PVNS/TGCT is a rare pathological entity affecting the synovium and tendon sheaths in young adults. This usually benign neoplasm is driven by overexpression of CSF1, in some cases as a result of a t(1;2) translocation which results in the fusion of the CSF1 gene to the COL6A3 promoter. CSF1 in turn attracts non-neoplastic inflammatory cells expressing CSF1 receptor (CSF1R) through a paracrine—
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