Şişman Çocuklarda Eritrosit Sedimentasyon Hızına Etki Eden Faktörlerin Araştırılması

Abstract

Objective: To determine the factors affecting the erytrocyte sedimentation rate ESR in healthy obese children Design: A randomized controlled study Materials and methods: Subjects are consist of 65 healthy obese children 29 female and 35 male aged 10 05±1 1 years range 6 75 to 12 years and 30 non obese healthy children 17 female and 13 male aged 10 04±1 6 years range 7 5 to 12 years In the obese and control groups haemoglobin concentration hematocrit number and mean corpuscular volume of red blood cells viscosities of blood and serum as well as levels of fibrinogen total protein albumin globulin IgG IgA IgM alpha 1 antitripsin ceruloplasmin haptoglobulin C reactive protein ferritin total lipid total cholestrerol triglyceride LDL cholesterol VLDL cholesterol and HDL cholesterol were determined and the relationships between these parameters and the ESR were investigated On the other hand ESR values of both groups and the parameters that might affect ESR were compared Results: Compared to the control group ESR was higher in obese children independent of age and sex while levels of other acute phase reactants such as ferritin C reactive protein ceruloplasmin and alpha 1 antitripsin were found normal In obese children haemoglobin concentration number of red blood cells blood viscosity serum viscosity as well as levels of fibrinogen haptoglobulin total lipid total cholesterol thriglyceride LDL cholesterol VLDL cholesterol were found elevated On the other hand HDL cholesterol levels and mean corpuscular volume of red blood cells were found decreased ESR was correlated with antropometric measurements such as body mass index weight to height percentage and skin folds thickness subscapular suprailiac biceps and triceps Significant correlations were also found between ESR and hemorrheological factors such as blood viscosity serum viscosity plasma fibrinogen serum haptoglobulin and serum LDL cholesterol As multiple regression analysis was done it was seen that ESR is affected primarily by plasma fibrinogen and serum haptoglobulin levels Conclusions: The results of this study are outlining that ESR is elevated in normal obese children while other acute phase reactants are normal and that this elevation is affected primarily by plasma fibrinogen and serum haptoglobulin levels Key words: Erytrocyte Sedimentation Rate Obesity Child