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Abstract
Thyroid cancer is usually diagnosed by ultrasound imaging and fine-needle aspiration biopsy. However, diagnosis of follicular thyroid carcinomas (FTC) is difficult because FTC lacks nuclear atypia and a consensus on histological interpretation. Diffuse optical tomography (DOT) offers the potential to diagnose FTC because it can measure tumor hypoxia, while image reconstruction of the thyroid is still challenging mainly due to the complex anatomical features of the neck. In this study, we attempted to solve this issue by creating a finite element model of the human neck excluding the trachea (a void region). By reconstruction of the absorption coefficients at three wavelengths, 3D tissue oxygen saturation maps of the human thyroid are obtained for the first time by DOT.
Highlights
The Diffuse optical tomography (DOT) images are shown on the T2weighted MR images
Whether the thyroid can be imaged accurately by DOT has been regarded as a seriously nontrivial question, but in this paper, we have shown that the whole shape of the thyroid can be reconstructed if the grid for the calculations excludes the trachea void region
This paper presents 3D absorption and StO2 images of an in vivo human thyroid by DOT
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The incidence of thyroid cancer has been increasing in many parts of the world over the past decades, thyroid cancer remains among the less common cancers [1,2]. The etiology of the increasing incidence is not established. An analysis of data from the Surveillance Epidemiology and End Results (SEER) database has indicated that the increase is due to improved detection and not to a rise in occurrence [3]. The worldwide increase cannot be explained by noting earlier discovery [1], and there is increasing interest in the diagnosis and treatment of thyroid cancers
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