Abstract
Clathrin-mediated endocytosis (CME) facilitates the internalization of many cargoes. Clathrin polymerization, endocytic accessory proteins recruitment, and changes in plasma membrane architecture are necessary steps to mediate the formation of clathrin-coated vesicles (CCVs). However, simultaneous analysis of clathrin dynamics and vesicle shape in living cells is challenging due to the limited axial resolution of fluorescence microscopes, and the heterogeneity and dynamicity of CME. This has fueled conflicting models of vesicle assembly and obscured the roles of flat clathrin assemblies.
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