Imaging Protein-Protein Interactions in Whole Cells and Living Animals

Abstract

These studies demonstrate that noninvasive molecular imaging of protein-protein interactions may enable investigators to determine how intrinsic binding specificities of proteins are regulated in a wide variety of normal and pathophysiologic conditions. These tools provide a platform for detection of regulated and small molecule-induced protein-protein interactions in intact cells and living animals and should enable a wide range of novel applications in biomedi-cine, drug discovery, chemical genetics, and proteomics research.