Abstract
Cancer is characterized by the often rapid and uncontrolled rate of cell growth. This alteration in growth pattern causes normal cells to become tumor cells. After undergoing a period of chemotherapy, some tumor cells become resistant to a variety of drugs, a phenomenon known as the multidrug resistance (MDR). One explanation for this change is the overexpression of P-glycoprotein in the drug-resistant cells. This membrane protein is capable of pumping drugs into the extracellular medium. Since the drugs do not accumulate, the tumor cells are not killed. In order to examine this protein, a contact mode AFM was used to image the cell membranes of both the normal and the MDR tumor cells. The four figures provided show the topographical information of the membranes and suggest that there are differences between the cell lines.
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