Abstract
Acromegaly can lead to structural alterations of joints and bones. Patients with acromegaly may, therefore, have musculoskeletal complaints. In this study, sacroiliac joints are investigated in patients with acromegaly. 33 patients with acromegaly were enrolled. Sacroiliac joints were examined by X-ray and magnetic resonance imaging (MRI). In acromegaly, sacroiliac joints were abnormal in 36% of the patients by X-ray and 12.1% by MRI. When current axial spondylarthritis (SpA) classification criteria were taken into account, 6.1% of acromegaly patients could be classified as non-radiographic axial SpA and 2% as radiographic axial SpA. Sacroiliac joints are frequently affected in acromegaly and thus this disorder mimics the features of AS and SpA. Acromegaly should be kept in mind in the differential diagnosis of AS and SpA.
Highlights
Is a rare disease characterized by the increased release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1)
Human leukocyte antigen (HLA)-B27 positivity, peripheral joint involvement, sacroiliitis, spondylitis, enthesitis, dactylitis, uveitis, inflammatory bowel disease and psoriatic skin lesions are found in SpA group diseases, which are subdivided into 2 categories: axial and peripheral[7,8]
AxSpA affects mainly the sacroiliac joints and the spine, and is categorised into 2 subtypes: non-radiographic axSpA and radiographic axSpA, including ankylosing spondylitis (AS). It is named as radiographic axial SpA if sacroiliitis is shown on X-ray; if sacroiliitis is detected by magnetic resonance imaging (MRI) but the X-ray is normal; it is considered to be a non-radiographic axSpA9
Summary
Is a rare disease characterized by the increased release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Human leukocyte antigen (HLA)-B27 positivity, peripheral joint involvement, sacroiliitis, spondylitis, enthesitis, dactylitis, uveitis, inflammatory bowel disease and psoriatic skin lesions are found in SpA group diseases, which are subdivided into 2 categories: axial (axSpA) and peripheral (pSpA)[7,8]. AxSpA affects mainly the sacroiliac joints and the spine, and is categorised into 2 subtypes: non-radiographic axSpA and radiographic axSpA, including ankylosing spondylitis (AS). It is named as radiographic axial SpA if sacroiliitis is shown on X-ray; if sacroiliitis is detected by MRI but the X-ray is normal; it is considered to be a non-radiographic axSpA9. Patients with acromegaly were examined for similarities of axSpA in our study
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