Abstract
Background An understanding of inflammation following myocardial infarction may be of importance in the development of novel therapeutics to limit the development of heart failure following myocardial injury. However, the quantification of inflammation in this setting continues to be challenging. Hybrid FDG PET/MR may offer a non-invasive in vivo solution through intrinsic registration of these complementary modalities. This study sought to validate its use in a canine model of myocardial infarction (MI).
Highlights
An understanding of inflammation following myocardial infarction may be of importance in the development of novel therapeutics to limit the development of heart failure following myocardial injury
In the 9 animals subject to ex vivo tissue analysis, there was a good correlation between FDG vs. Indium concentrations across the range of Tc-DTPA values, except in regions of microvascular obstruction and low Tc-DTPA, where Indium levels were much higher than those of FDG
Reduced FDG activity within regions of microvascular obstruction may be secondary to limited delivery of tracer to these regions following bolus injection of the tracer
Summary
An understanding of inflammation following myocardial infarction may be of importance in the development of novel therapeutics to limit the development of heart failure following myocardial injury. The quantification of inflammation in this setting continues to be challenging. Hybrid FDG PET/MR may offer a non-invasive in vivo solution through intrinsic registration of these complementary modalities. This study sought to validate its use in a canine model of myocardial infarction (MI)
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