Abstract
Finding and identifying hepatic neoplasms in patients with diffuse liver disease is one of the most challenging tasks in diagnostic radiology. This chapter discusses the performance of contrast enhanced CT (CECT), delayed iodine CT scan (DIS), magnetic resonance imaging (MR) and ultrasound (US) in detection and characterization of focal liver lesions in patients with diffuse liver disease. First, the sensitivity and specificity of these various imaging modalities for detection of focal lesions in patients with normal liver parenchyma is summarized. In the second part, the impact of diffuse liver disease on lesion detection is outlined. Finally, future strategies for the use of contrast agents targeted to liver in patients with diffuse liver disease are outlined.
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