Abstract
AbstractThe subbasal corneal nerve plexus may serve as an important biomarker in ocular surface disease and ocular as well as systemic neuropathies. Changes in number and density of nerves, “beadings” and or tortuosity correlate to clinical signs of Dry Eye Disease. The same is true for atopic keratoconjunctivitis where – in addition – the number of perineural inflammatory cells was significantly increased. In patients with type 1 diabetes mellitus, the corneal subbasal nerve plexus was abnormal in 50% although classified as “normal” by the clinical and electrophysiological based tests for peripheral neuropathies. Although in vivo confocal microscopy is a wonderful tool to assess corneal nerves as reliable biomarkers, it is not generally available, the quality of different equipment may vary, and the analysis of nerves is still time‐consuming.
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