Abstract
Purpose: Cartilage damage is one of the central hallmarks of osteoarthritis (OA). Classical imaging modalities like X-ray and magnetic resonance imaging, mainly allow the identification of advanced cartilage damage. Development of cartilage destruction is highly variable among OA patients and the detection of early cartilage damage using sensitive molecular imaging tracers will likely facilitate an early diagnosis and more precise monitoring of disease progression. Moreover, this will allow for non-invasive testing of possible new therapeutics.
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