Abstract
Imaging latent tuberculosis infection with radiolabeled nitroimidazoles.
Highlights
In a previous paper, an overview of the use of PET/CT in the management of tuberculosis (TB) was provided and the potential role of nitroimidazole imaging in LTBI was considered [1]
Exposure of Mycobacterium tuberculosis (Mtb) to progressive hypoxia in vitro induces a dormant state characterized by reduced replication and metabolism analogous to that postulated for bacilli in LTBI
Mtb has been shown to enter microaerophilic nonreplicating persistent (NRP) stage 1, if the dissolved oxygen content falls below 1 %
Summary
An overview of the use of PET/CT in the management of tuberculosis (TB) was provided and the potential role of nitroimidazole imaging in LTBI was considered [1]. If the oxygen content further drops to approximately 0.06 %, the bacilli enter NRP stage 2, which is accompanied by reduced susceptibility to standard antiTB drugs but increased susceptibility to nitroimidazole drugs [2]. The invasiveness of these procedures as well as their susceptibility to sampling error has encouraged the development of image-based methods for detecting and quantifying hypoxia [4].
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