Abstract
With advanced age, articular calcium pyrophosphate crystal deposition (CPPD) is common. Defining who has CPPD is of growing importance, given increases in longevity in many countries and the frequent association of chondrocalcinosis with osteoarthritis. Chondrocalcinosis detected by plain radiography serves as a major screening tool, but how many and which sites to screen have not been adequately defined in the past. The work of Abhishek and colleagues in the previous issue of Arthritis Research and Therapy sheds new light on the incomplete information from knee radiographs, and helps position us to learn more about the epidemiology, pathophysiology, diagnosis, and clinical impact of CPPD.
Highlights
With advanced age, articular calcium pyrophosphate crystal deposition (CPPD) is common
Abhishek and colleagues performed a cross-sectional study of 3,170 subjects embedded in the Genetics of Osteoarthritis and Lifestyle (GOAL) study [1]
In the GOAL study, approximately one-third of subjects had clinically severe hip OA, or clinically severe knee OA, or did not have knee or hip OA. Since this population is skewed for high prevalence of hip or knee OA, the distribution of CC was analyzed for the subgroup without radiographic hip or knee OA
Summary
Articular calcium pyrophosphate crystal deposition (CPPD) is common. Calcium pyrophosphate crystal deposition (CPPD) is a common finding in many fibrocartilages and hyaline articular cartilages of larger joints, and in certain tendons and soft tissues [1,2,3,4].
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