IMAGING | Imaging Characterization of Familial Temporal Lobe Epilepsies

Abstract

Family history of seizures and epilepsy is frequent in patients with temporal lobe epilepsy (TLE). Detailed characterization of affected family members is crucial for defining the familial epilepsy syndrome. Patients with clinical and EEG presentation of TLE can be identified in the context of different epilepsy syndromes. There are two groups of well-characterized familial TLE, according to the evidence for predominant involvement of mesial or neocortical structures: Familial mesial temporal lobe epilepsy (MTLE) and familial TLE with auditory auras.