Imaging Findings of Solitary Plasmacytoma of the Cranium

Shrestha Sukriti,Zhao Xinxiang,Zhu Li

doi:10.26502/acmcr.96550048

Abstract

Solitary plasmacytoma of bone (SBP) are extremely rare and limited in the English literature. The most common locations in the skull are sphenoid bone, juxtasellar region, petrous apex and cerebral convexity or falx. SBP has higher risk of advancing to Multiple Myeloma within the duration of 2-4 years. Here we report two cases involving the cranium, both the cases initially mis-diagnosed as meningioma and after histopathology report confirmed as plasmacytoma. Further laboratory investigations were made to rule out multiple myeloma and its systemic involvement. We will also further discuss about the CT and MRI features and the most common differential diagnosis of SBP.

Highlights

Solitary plasmacytoma is an early stage malignancy with a clinical course that lies between MGUS and multiple myeloma (MM) in the spectrum of plasma cell dyscrasia
It has been divided into two types: one that grows within the axial skeleton known as solitary plasmacytoma of bone (SPB) and the other within soft tissue called extramedullary plasmacytoma (EMP)
Arch Clin Med Case Rep 2018; 2 (6): 231-240 meningioma and after histopathology report confirmed as plasmacytoma

Summary

Introduction

Solitary plasmacytoma is an early stage malignancy with a clinical course that lies between MGUS (monoclonal gammopathy of undertermined significance) and multiple myeloma (MM) in the spectrum of plasma cell dyscrasia. It has been divided into two types: one that grows within the axial skeleton known as solitary plasmacytoma of bone (SPB) and the other within soft tissue called extramedullary plasmacytoma (EMP). Skull involvement occurs mainly in cranial vault, skull base, dura and orbit [1]. Cranial vault and cranial base lesions are suggested to have higher risk of evolution to MM than dural lesions [1]. We report two cases involving the cranium, both the cases initially diagnosed as

Results

Discussion

Conclusion