Abstract
Primary bone lymphoma (PBL) is a less frequent type of extranodal lymphoma, which is defined as a single skeletal tumor or multiple bone lesions without visceral or lymph node involvement. Most published cases have reported diffused large B cell lymphoma (DLBCL) of PBL, and the prognosis is good after conventional treatment. Primary T-cell lymphoma is extremely rare in the literature. The clinical symptoms, imaging findings, diagnosis, treatment and prognosis of primary T-cell lymphoma of bone are still unclear. The case details a young male patient who was treated for bone tuberculosis and was diagnosed with T-cell lymphoma during an open surgical biopsy. Further imaging evidence showed the lymphoma was localized within the femur. The patient responded poorly to combined chemo- and radiotherapy. He was confirmed with local lung metastases 11 months later and died at the 17th month of onset. I would like to provide PBL entities with some rare information about primary bone peripheral T-cell lymphoma and discuss the best strategy for the treatment of rare PBL subtypes.
Highlights
Lymphomas commonly occur in the lymph nodes, and extranodal sites are less frequent origins of lymphomas
As to the development of lymphoma in molecular biology, chemotherapy was conducted on Primary bone lymphoma (PBL) patients and showed better outcomes, so radiotherapy was no longer used to the multifocal patients
Beal et al [22] conducted a long-term follow-up of 82 PBL patients, and showed that the 5-year Overall survival (OS), cause-specific survival (CSS), and freedom-from-treatment failure (FFTF) for patients treated with combined modality versus singlemodality therapy were 95% versus 78% (P = .013), 90% versus 67% (P = .025) and 95% versus 83% (P = .065) respectively
Summary
Lymphomas commonly occur in the lymph nodes, and extranodal sites are less frequent origins of lymphomas. Primary bone lymphoma (PBL) accounts for 4–5% of extranodal non-Hodgkin’s lymphomas and less than 1% of all malignant lymphomas, and 7% of malignant primary bone tumors [1]. Parker and Jackson reported 17 cases in 1939 [3] under the designation reticulum cell sarcoma of bone, establishing PBL as a distinct clinical entity. It must be distinguished from the more common condition characterized by secondary bone involvement of systemic lymphomas. More than 20% of lymphoma patients have secondary bone involvement [4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
