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Abstract
BackgroundFibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis. Objectives of our study were to analyze contrast material uptake in hepatobiliary phase imaging (HBP) in gadoxetic acid-enhanced liver MRI in patients with FLC and to characterize imaging features in sequence techniques other than HBP.MethodsIn this retrospective study on histology-proven FLC, contrast material uptake in HBP was quantitatively assessed by calculating the corrected FLC enhancement index (CEI) using mean signal intensities of FLC and lumbar muscle on pre-contrast imaging and HBP, respectively. Moreover, enhancement patterns in dynamic contrast-enhanced MRI and relative signal intensities compared with background liver parenchyma were determined by two radiologists in consensus for HBP, diffusion-weighted imaging using high b-values (DWI), and T2 and T1 weighted pre-contrast imaging.ResultsIn 6 of 13 patients with FLC gadoxetic acid-enhanced liver MRI was available. The CEI suggested presence of HBP contrast material uptake in all FLCs. A mean CEI of 1.35 indicated FLC signal increase of 35% in HBP compared with pre-contrast imaging. All FLCs were hypointense in HBP compared with background liver parenchyma. Three of 6 FLCs had arterial hyperenhancement and venous wash-out. In DWI and T2 weighted imaging, 5 of 6 FLCs were hyperintense. In T1 weighted imaging, 5 of 6 FLCs were hypointense.ConclusionHepatobiliary uptake of gadoxetic acid was quantitatively measurable in all FLCs investigated in our study. The observation of hypointensity of FLCs in HBP compared with background liver parenchyma emphasizes the role of gadoxetic acid-enhanced liver MRI for non-invasive diagnosis of FLC and its importance in the diagnostic work-up of indeterminate liver lesions.
Highlights
Fibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis
Fibrolamellar hepatocellular carcinoma (FLC) is a very rare form of primary hepatic cancer accounting for approximately 5% of all hepatocellular carcinomas (HCCs) [1]
From a radiologists’ point of view, it is of utmost importance to distinguish FLC from focal nodular hyperplasia (FNH)
Summary
Fibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis. Objectives of our study were to analyze contrast material uptake in hepatobiliary phase imaging (HBP) in gadoxetic acid-enhanced liver MRI in patients with FLC and to characterize imaging features in sequence techniques other than HBP. Palm et al Cancer Imaging (2018) 18:9 young patients without chronic liver disease as well, but is always benign, has no potential for malignant transformation and requires no specific therapy. Considering MRI after injection of gadoxetic acid as a liverspecific contrast agent eliminated significantly via the biliary system (Primovist or Eovist; Bayer Vital, Leverkusen, Germany), it is well known that FNH typically shows enhancement during hepatobiliary phase imaging due to hepatocellular uptake of contrast material [8]. There are incomplete data investigating the behavior of FLC on MRI using liver-specific contrast material
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