Imaging changes over 18 months following stereotactic radiosurgery for brain metastases: both late radiation necrosis and tumor progression can occur

Abstract

Following stereotactic radiosurgery (SRS) for brain metastases, the median time range to develop adverse radiation effect (ARE) or radiation necrosis is 7-11months. Similarly, the risk of local tumor recurrence following SRS is < 5% after 18months. With improvements in systemic therapy, patients are living longer and are at risk for both late (defined as > 18months after SRS) tumor recurrence and late ARE, which have not previously been well described. An IRB-approved, retrospective review identified patients treated with SRS who developed new MRI contrast enhancement > 18months following SRS. ARE was defined as stabilization/shrinkage of the lesion over time or pathologic confirmation of necrosis, without tumor. Local failure (LF) was defined as continued enlargement of the lesion over time or pathologic confirmation of tumor. We identified 16 patients, with a median follow-up of 48.2months and median overall survival of 73.0 months, who had 19 metastases with late imaging changes occurring a median of 32.9months (range 18.5-63.2months) after SRS. Following SRS, 12 lesions had late ARE at a median of 33.2months and 7 lesions had late LF occurring a median of 23.6months. As patients with cancer live longer and as SRS is increasingly utilized for treatment of brain metastases, the incidence of these previously rare imaging changes is likely to increase. Clinicians should be aware of these late events, with ARE occurring up to 5.3years and local failure up to 3.8years following SRS in our cohort.