Imaging Cardiovascular Development: Insights into Congenital Disease

Abstract

With recent advances in imaging technology, we now have the ability to detect, measure and test mechanisms that are critical for the formation of the early cardiovascular system. I will summarize how we are using 3D and 4D imaging technology together with genetics, to define the mechanisms that underlie mutants phenotypes using the mouse as a model system. In depth studies of single gene models as well as systematic approaches to annotate phenotypes in mouse mutants from large scale screens will be discussed.