Imaging and navigation of remote controlled nanostructured carriers for theranostics (Conference Presentation)

Abstract

The modern medicine requires the new type of drug delivery carriers that will combine functions of in vivo navigation and visualization ability to deploy drug in controllable manner, including external triggering. This combination can be realized by multifunctional carriers produced by layer-by-layer assembly method. The carrier biodistribution can be controlled by a chosen mode of in vivo administration. Realization for chemical targeted delivery based on surface modification are not working well in vivo due to the corona effect [Kreyling W. et al., Nature Nanotech., 2015, 619]. Thus, physical targeting of drug delivery is more promising approach. It can be realized by gradient of magnetic field [Voronin D. et al., ACS App. Mater. & Interfaces, 2017, 6885], optical tweezers [Stetciura I. et al., Analyst, 2015,4981]. It was demonstrated that the sensitivity of nanostructured carriers to external influences as laser irradiation, ultrasound treatment can be changed by variation of volume fraction and chemical composition of inorganic nanoparticles in the carrier shell [Korolovych V. et al., PCCP, 2016,2389]. Same approach is applied for nanostructured carriers (NCs) imaging by MRI [German S. et al., PCCP, 2016, 32238], OCT [Genina E. et al., Biomed.Opt.Express, 2016, 2082] and photoacoustic method [Yashchenok A. et al., J. Biophotonics, 2016, 792] using magnetite and gold nanoparticles as contrast agents, respectively. Obtained NCs can be used as drug delivery systems including drug depot, combined much functionalities as navigation and visualization, in vivo monitoring of biochemical process, remote activated release of bioactive substances.