Abstract
Quercetin is a hydrophobic bioflavanoid with versatile potentials, including anti-cancer property. The study aims to prepare a quercetin based nanocomposite with theranostic potential ie., for use in diagnostics and cancer therapeutics. Nanocomposite comprising of iron/gold nanohybrid particles, coated with oleyl chitosan, conjugated with folic acid and loaded with quercetin was synthesised and physico-chemically characterised. Magnetic resonance imaging (MRI) and computed tomography (CT) phantom images displayed the effectiveness of quercetin nanocomposite (QNC) to be used as contrast agents for MRI and CT respectively. The preferential cytotoxicity exhibited by QNC towards cancer cell line (MDA-MB-231) and non-toxic effect towards normal cell line (NIH 3T3), is yet another promising aspect of QNC. The results prove that, QNC could be used as dual modality contrast agent for both MRI and CT, and it also demonstrated significant anti-cancer effect on tumor cell line.
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