Image Risk Assessment of the Thyroid Cancer Model Based on Discriminant Analysis and the Value of TAP and CEA Combined Detection.

Bin Wang,Shaolei Lang,Li Liang,Yinxia Xu,Shengliang Wang,Yan Xue,Yang Yang,Dilbag Singh

doi:10.1155/2021/8836288

Abstract

The incidence rate of thyroid disease is increasing rapidly worldwide, and the number of thyroid patients is increasing. In this study, serum TAP (tumor abnormal protein) and CEA (carcinoembryonic antigen) were used to detect patients with thyroid nodules of class IV and above to explore the value of serum TAP combined detection of CEA in the risk assessment of thyroid cancer. In this paper, 400 patients with thyroid nodules above class IV diagnosed by physical examination in our hospital health management center from January 2019 to June 2021 were included in the study. Combined with the pathological test results, the patients were divided into risk groups. At the same time, different groups of serum TAP and CEA levels were detected by aggregation and electrochemiluminescence methods, and serum TAP and CEA levels were analyzed according to the pathological diagnostic indicators of CEA levels. The results showed that the levels of serum TAP and CEA in patients with thyroid cancer were significantly higher than those in patients with benign thyroid diseases, and the difference was statistically significant (P < 0.05). The sensitivity, specificity, and AUC under the ROC curve area of serum TAP were 85.25%, 85.06%, and 0.605, respectively. The sensitivity, specificity, and AUC under the ROC curve area of serum CEA were 89.85%, 88.00%, and 0.627, respectively. The sensitivity, specificity, and AUC under the ROC curve area of serum TAP combined with CEA were 96.84%, 96.79%, and 0.915, respectively. Therefore, the combined detection of serum TAP and CEA has a high early screening value in thyroid cancer.

Highlights

At present, the detection rate of thyroid cancer is still low, and many methods cannot balance the sensitivity and specificity threshold, leading to that many patients cannot be diagnosed until they are seriously ill
Given the results of blood glucose detection by some scholars, this paper proposes a diagnostic method of thyroid cancer detection by carcinoembryonic antigen (CEA) combined with TAP
Pistollato et al believed that early thyroid cancer may have a potential protective effect on thyroid cancer. is effect seems to last as long as six years after the diagnosis of thyroid cancer. e mechanism may be that metformin, an antithyroid cancer drug, can inhibit cell cycle progression and induce apoptosis. is leads to the antimitotic effect and reduces the growthstimulating effect of insulin [1]

Summary

Introduction

The detection rate of thyroid cancer is still low, and many methods cannot balance the sensitivity and specificity threshold, leading to that many patients cannot be diagnosed until they are seriously ill. Detweiler et al.’s study found that the incidence rate of thyroid cancer increased by 20% compared with patients with low CEA content, and the risk was mainly in women. The detection rate of thyroid cancer is still low, so this paper uses TAP and CEA combined detection to predict the risk of thyroid cancer in patients with thyroid nodules of class IV and above and analyzes its value. Patients were divided into risk groups according to the results of pathological examination, and serum TAP and CEA levels in different groups were detected and compared by agglutination and electrochemiluminescence. The diagnostic indexes of serum TAP and CEA levels were analyzed based on the pathological results to analyze the value of these two indicators in the diagnosis of thyroid cancer

Detection Index and Evaluation Method

Experimental Design

Determination Method

Results and Discussion