Abstract
Performance testing of small animal PET scanners is very important to ensure the high performance required for this particular type of PET scanner. In this sense, National Electrical Manufactures Association (NEMA) published its NU 4/2008 standards, a consistent and standardized methodology for measuring scanner performance parameters for small animal PET imaging. Imaging capabilities of the scanner LabPET SOLO 4 were tested during two years according NEMA NU 4/2008 methodology. Results indicates that the equipment, despite a decade of use, presents performance appropriated and similar to performance of equipments reported in Literature.
Highlights
The importance of small animal Positron Emission Tomography (PET) has increased during the last decades as a valuable tool to noninvasive in vivo studies of preclinical animal models, to contribute in the drug development, to evaluate novel PET tracers and to in vivo therapy monitoring [1, 2]
Our results suggests that measurements of image quality parameters for small animal PET scanner based on a single image section should be considered with caution, especially when a manufacturer is disclosing their equipment features
Imaging performance of LabPET SOLO 4 scanner was studied during two years
Summary
The importance of small animal Positron Emission Tomography (PET) has increased during the last decades as a valuable tool to noninvasive in vivo studies of preclinical animal models, to contribute in the drug development, to evaluate novel PET tracers and to in vivo therapy monitoring [1, 2]. A single animal can be studied multiple times during the course of the preclinical evaluation. Due to differences in size between humans and rodents, PET scanners dedicated to small animals imposes higher performance requirements than does clinical PET scanners [3]. Guidelines to evaluation small animal PET scanners performance were introduced last decade [4] while guidelines for clinical PET scanner evaluation have been available for a long time [5, 6, 7, 8]. The National Electrical Manufactures Association (NEMA) in its NEMA Standards Publication NU 4/2008 [4] presents a consistent and standardized methodology for evaluating the performance of small-animal PET scanners. The PET performance should be evaluated by the following parameters: 1) Spatial Resolution; 2) Sensitivity; 3) Coincidence Events Rate; and 4) Image quality [4]
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