Abstract
We propose two computational frameworks for the assessment of contractile responses of enzymatically dissociated adult and neonatal cardiac myocytes. The proposed methodologies are variants of mathematically sound and computationally robust algorithms very well established in the image processing community. The computational pipeline for assessing contractility in adult cardiocytes comprises the following stages: digital video recording of the contracting cell, edge preserving total variation-based image smoothing, segmentation of the smoothed images, contour extraction from the segmented images, shape representation by Fourier descriptors, and contractility assessment.
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