Abstract
Background Central retinal artery occlusion (CRAO) usually present different histopathologic changes in the outer retinal layers at acute and non-acute phase.Spectral-domain optical coherence tomography (SD-OCT) and short-wave length fundus autofluorescence (SW-AF) are non-invasive imaging techniques. Objective This study was to observe the image features of SD-OCT and SW-AF in the eyes with CRAO. Methods The images of SD-OCT, SW-AF, fundus fluorescein angiography (FFA) and color fundus picture were retrospectively compared and analyzed in 38 eyes of 36 patients with CRAO, who were diagnosed and examined in Xijing Hospital of Fourth Military Medical University from March 2012 to January 2014.The pragmatic value of SD-OCT and SW-AF in the diagnosis of acute CRAO and non-acute CRAO was evaluated. Results Acute CRAO was found in 68.42% patients (26/38), including 2 eyes with ciliary artery; while non-acute CRAO was included in 31.58% (12/38). The edema, thickening and structural disorder of the inner layers of retinas were exhibited in SD-OCT images, and SW-AF was weakened in the acute-stage of CRAO, and the range and degree of disease in the SD-OCT and SW-AF were in accordance with that in the FFA and color fundus picture.In addition, in non-acute CRAO, the inner retinal layer was thinning due to the decrease of retinal layers, but the thickness and structure were normal in the outer retinal layer in SD-OCT, and SW-AF image was close to normal. Conclusions SD-OCT can reveal the edema and thickness changes of retinas in acute and non-acute CRAO eyes, while SW-AF can offer the abnormal information of retinal lesions in acute CRAO eyes.Being noninvasive examination approachs, SD-OCT and SW-AF play important roles in the diagnosis and differential diagnosis of CRAO. Key words: Tomography, optical coherence; Arterial occlusive diseases/pathology; Retinal artery; Acute disease; Diagnostic imaging; Humans; Retrospective studies; Autofluorescence
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