Abstract
Deoxyribonucleic acid (DNA) nanostructure-based data encoding is an emerging information storage mode, offering rewritable, editable, and secure data storage. Herein, a DNA nanostructure-based storage method established on a solid-state nanopore sensing platform to save and encrypt a 2D grayscale image is proposed. DNA multi-way junctions of different sizes are attached to a double strand of DNA carriers, resulting in distinct levels of current blockades when passing through a glass nanopore with diameters around 14nm. The resulting quaternary encoding doubles the capacity relative to a classical binary system. Through toehold-mediated strand displacement reactions, the DNA nanostructures can be precisely added to and removed from the DNA carrier. By encoding the image into 16 DNA carriers using the quaternary barcodes and reading them in one simultaneous measurement, the image is successfully saved, encrypted, and recovered. Avoiding any proteins or enzymatic reactions, the authors thus realize a pure DNA storage system on a nanopore platform with increased capacity and programmability.
Highlights
Deoxyribonucleic acid (DNA) nanostructure-based data encoding is an and readout speed,[11,12,13,14] but it is almost helpless for DNA nanostructure-based emerging information storage mode, offering rewritable, editable, and secure storage
We initially investigated the design of DNA structures detectable on the ≈14 nm nanopore sensing platform.[19]
When the DNA carrier is driven through the nanopore under an electric force in an unfolded configuration, a first level current drop (Ievent) is recorded (Figure 1b)
Summary
Deoxyribonucleic acid (DNA) nanostructure-based data encoding is an and readout speed,[11,12,13,14] but it is almost helpless for DNA nanostructure-based emerging information storage mode, offering rewritable, editable, and secure storage. 14 nm diameter nanopores,[19] we use three DNA junction structures of different sizes (4-way junction, 6-way junction, and 12-way junction) to generate a quaternary encoding system (0–3) on the long linear DNA carrier, which increases the data density
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