Abstract
The viability of a three-component enzyme activated image contrast system was demonstrated using a family of tyrosine–chromophore conjugates linked by an inert spacer. A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen and α-chymotrypsin, releasing free fluorophore via cleavage of a three-component system.
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