ILT receptors at the interface between lymphoid and myeloid cells.

Abstract

Immunoglobulin (Ig)-like transcripts (ILT) receptors, also known as monocyte/macrophage Ig-like receptors (MIRs) or leukocyte Ig-like receptors (LIRs)[1, 2], constitute a family of receptors which belong to the immunoglobulin superfamily. They are characterized by either 2 or 4 homologous extracellular C-2 type Ig-like domains or by different transmembrane and cytoplasmic domains. One subset of ILT receptors (ILT2, ILT3, ILT4, ILT5 and LIRE) displays long cytoplasmic tails containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and delivers inhibitory signals by recruiting SHP-1 protein tyrosine phosphatase [3–5]. A second subset of ILT receptors (ILT1, ILT7, ILT8 and LIR6) is characterized by the presence of a positively charged amino acid residue within the transmembrane region and by a short cytoplasmic tail with no obvious signal transduction motifs. These receptors mediate cell activation by associating with the gamma chain of Fc receptors (FcR’y) [6]. FcR’y recruits protein tyrosine kinases through a cytoplasmic immunoreceptor tyrosine-based activation motif (1TAM).KeywordsInhibitory ReceptorHigh Endothelial VenuleNatural Killer Cell ReceptorInflame Lymph NodeCD16 High CD14These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.