Abstract
Kuding tea is implicated in alleviating metabolic disorders in traditional Chinese medicine. However, the role of Ilex latifolia Thunb (kuding tea), one of the large leaf kuding tea species, in the prevention of the development of obesity remains to be determined. We show here that 7-week-old male mice treated with an Ilex latifolia Thunb supplement for 14 weeks were resistant to HFD-induced body weight gain and hepatic steatosis, accompanied by improved insulin sensitivity. Ilex latifolia Thunb supplementation dramatically reduced the systemic and tissue inflammation levels of mice via reducing pro-inflammatory cytokine levels, increasing anti-inflammatory cytokine levels in the circulation and inhibiting p38 MAPK and p65 NF-κB signaling in adipose tissue. Together, these results indicate that Ilex latifolia Thunb protects mice from the development of obesity and is a potential compound pool for the development of novel anti-obesity drugs.
Highlights
Green tea and kuding tea are two of the most popular beverages in China[1,2]
Rosiglitazone was used as an inducer to promote the adipocyte differentiation of OP9 cells, and an aqueous extract of Ilex latifolia Thunb was added into the medium from day 1 to day 5
After mice were fed a high-fat diet (HFD) for 14 weeks, we found that mice treated with different dosage of aqueous extract of Ilex latifolia Thunb displayed significantly reduced body weight gain compared to mice without treatment with Ilex latifolia Thunb (Figs 2a and S3)
Summary
Green tea and kuding tea are two of the most popular beverages in China[1,2]. Green tea has been well studied for its health benefits in previous reports, but the biological functions of kuding tea are not as well studied[3,4,5]. Previous studies have investigated pharmaceutical functions of Ilex kudingcha C.J. Tseng, including anti-oxidant, anti-hypertensive, anti-obesity, anti-diabetic, hepatoprotective and anti-cancer roles[8,9,10]. Aqueous extract of Ilex latifolia Thunb prevented body weight gain and hepatic steatosis, enhanced insulin sensitivity and reduced chronic inflammation in mice. The alleviation of body weight gain by Ilex latifolia Thunb suggested that herbal supplements of Ilex latifolia Thunb could be used in the intervention of development of obesity
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