Abstract
Previous investigations have shown an inhibition of gastrointestinal epithelial cell proliferation in acutely uremic mice. This paper gives the results of an autoradiographic investigation with3H-thymidine of the effect of acute renal failure on ileal epithelial cell migration. Acute renal failure was produced by urinary outflow obstruction and control mice subjected to sham operation. The mean number of cell positions between the cryptvillus junction and the leading labeled cell 30 hours after operation was decreased in the uremic group (P<0.01). No significant difference was found in the number of cells per villus column. Estimates showed a decrease in mean migration rate from 0.69 to 0.55 positions per hour and an increase in the life span of villus cells from 54.2 to 73.8 hours. Decreased crypt and villus cell renewal may contribute to the development of uremic gastrointestinal lesions.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
