Abstract
Inflammation induced by physical, chemical, bacterial, viral or parasitic means all have one common consequence, the dramatic change in serum concentrations of a group of proteins known as the acute phase reactants (APR’s). The majority of APR’s are of hepatic origin. An important mediator in the liver acute phase response is IL-6. Mast cells have recently been recognized as a potential source of several cytokines. Mouse mast cell lines have been demonstrated to produce IL-3, IL-4, IL-5, IL-6 and TNFα on activation with ionophore or cross linkage of FCeRI. Mouse bone marrow derived mast cells are known to produce both IL-3 and GM-CSF. We have no information concerning cytokine production by mast cells derived directly from an animal source.
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