Abstract
BackgroundDifferent inflammatory and immune cytokines play a key role in the development of cirrhosis of liver (CL). To investigate the association between interleukin-6,10 (IL-6,10) genes polymorphisms and CL risk through comparison of the allele and genotype distribution frequencies by meta-analysis.MethodsA literature search covered with the PubMed, Embase, Cochrane Library, Web of Science, Google Scholar, SinoMed (CNKI and Wanfang) through 20th April, 2021. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations.ResultsAfter a comprehensive search, three common polymorphisms (rs1800872, rs1800871, rs1800896) in IL-10 gene were selected, and three common polymorphisms (rs1800795, rs1800796, rs1800797) in IL-6 gene were also identified. The important finding was that IL-10 rs1800872 was a risk factor for CL development. For example, there has a significantly increased relationship between rs1800872 polymorphism and CL both in the whole group (OR: 1.30, 95%CI: 1.01–1.67 in heterozygote model), Asian population (OR: 1.40, 95%CI: 1.03–1.88 in heterozygote model) and hospital-based source of control (OR: 1.40, 95%CI: 1.01–1.96 in dominant model). In addition, significant association was found between rs1800896 and primary biliary cirrhosis subtype disease (OR: 1.30, 95%CI: 1.01–1.68 in allelic contrast model). No association was observed in all three polymorphisms in IL-6 gene.ConclusionOur present study suggests that the IL-10 rs1800872 and rs1800896 polymorphisms is potentially associated with the risk of CL susceptibility.
Highlights
Different inflammatory and immune cytokines play a key role in the development of cirrhosis of liver (CL)
With the implementation of HBV vaccination program and the application of effective anti HBV and HCV drugs in high endemic areas, the rate of liver cirrhosis caused by hepatitis gradually decreased, and the number of cases caused by NAFLD gradually increased [7]
In order to overcome the factors of sample size, regional and ethnic differences, our study summarized all published literatures related to the relationship between IL-6 and IL-10genes polymorphisms and CL by metaanalysis, to comprehensively evaluate the relationship between several polymorphisms and CL, and to provide evidence-based medical research basis for the etiology of CL
Summary
Different inflammatory and immune cytokines play a key role in the development of cirrhosis of liver (CL). Cirrhosis is the 11th leading cause of death worldwide, with a total burden of about 123 million deaths, of which about one tenth is decompensated [2, 3]. With the implementation of HBV vaccination program and the application of effective anti HBV and HCV drugs in high endemic areas, the rate of liver cirrhosis caused by hepatitis gradually decreased, and the number of cases caused by NAFLD gradually increased [7]. NAFLD is the commonest etiology worldwide, affecting 1 in 4 adults [8], and the progressive form that leads to patient with NAFLD, is predicted to increase by 63% between 2015 and 2030, representing a global cohort of at least 100 million individuals [9]
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