Abstract
IL1R1, encoding interleukin 1 receptor type 1, is located in the IL-1 gene cluster and is involved in the pathogenesis of hand, hip, and knee osteoarthritis (OA) in different ethnicities. However, the link between IL1R1 polymorphisms and OA risk in the Chinese Han population is unknown. We studied the association between five IL1R1 polymorphisms (rs10490571, rs12712127, rs956730, rs3917225, and rs3917318) and OA risk by analyzing the genotypes of 298 knee OA patients and 297 controls using Sequenom MassARRAY technology. Logistic regression analysis after adjusting for gender and age revealed significant differences in the allele frequencies of IL1R1 rs956730 and IL1R1 rs3917225 between patients and controls. In addition, IL1R1 rs3917225 was associated with increased risk of knee OA with or without adjustment by age and gender in the dominant model (adjusted OR= 1.47, 95%CI: 1.04-2.07, P = 0.030), the recessive model (adjusted OR= 1.75, 95%CI: 1.08-2.85, P= 0.023), and the additive model (adjusted OR= 1.40, 95%CI: 1.09-1.79, P = 0.007). This study is the first to report that IL1R1 polymorphisms are associated with knee OA susceptibility in the Northwestern Chinese Han population.
Highlights
Osteoarthritis (OA) is an age-related degenerative disorder that predominantly occurs in the middle aged and older people
Allele and genotype frequency distribution between knee OA patients and controls The allele and genotype frequencies of the IL1R1 polymorphisms are presented in Table 2 and 3
The frequency of the “G” allele of IL1R1 rs3917225 was different for patients in comparison to controls (41.3% versus 33.7%). and showed increased risk (OR= 1.38, 95%confidence interval (CI): 1.09-1.75, P= 0.007) of knee OA (Table 3)
Summary
Osteoarthritis (OA) is an age-related degenerative disorder that predominantly occurs in the middle aged and older people. Recent evidence demonstrates that OA is an inflammatory disease that affects large weight-bearing joints, such as hips and knees [1]. The secretion of IL-1β, the active form of IL-1 during inflammation, is increased in the OA-affected cartilage and synovial cells [7]. Moos and others found a 10-fold up-regulation of IL1β protein and mRNA in human OA-affected cartilage compared to normal articular cartilage [8]. IL1R1, that encodes cytokine receptor for IL1 is located on 2q12.1. It affects NF-κB signaling by combining with IL-1 on the cell surface and upregulates inflammation [9]. Mukundan and others reported IL-1R1 mRNA expression in human OA-affected cartilage [7]. A genome wide scan by Leppavuori and others identified a candidate www.impactjournals.com/oncotarget
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
