Abstract
// Chongya Huang 1 , Lijun Mei 2 , Ajing Wang 3 and Xian Zhang 4 1 School of Medicine, Xi'an Jiaotong University, Xi’an, Shaanxi 710061, China 2 Department of Blood Transfusion, Ankang Central Hosipital, Ankang, Shaanxi 725000, China 3 Department of Outpatient, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China 4 Department of Clinic Laboratory, Xi’an Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi 710021, China Correspondence to: Xian Zhang, email: xianzhangMD@163.com Keywords: chronic obstructive pulmonary disease (COPD); IL18; single nucleotide polymorphism (SNPs); case-control study Received: November 09, 2017 Accepted: December 06, 2017 Published: January 02, 2018 ABSTRACT Chronic obstructive pulmonary disease (COPD) is a kind of lung disease with high morbidity and mortality. Genetic polymorphisms of IL18 have been associated with respiratory system disease such as asthma, pulmonary tuberculosis, and lung cancer; however, little information is found about the association between IL18 polymorphisms and risk of COPD. We investigated the association between single nucleotide polymorphisms (SNPs) in IL18 and COPD risk in a case–control study that included 300 COPD cases and 300 healthy controls. Five SNPs were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for gender and age. In the genotype model analysis, we determined that rs2043055 polymorphism had an increased effect on the risk of COPD (GG versus AA: OR = 5.29; 95% CI = 1.15–24.35; p = 0.006). In the genetic model analysis, we identified four SNPs associated with COPD risk under recessive model. The “GG” genotype of rs2043055 and rs187238 were associated with increased risk of COPD (rs2043055: OR = 5.13, 95% CI = 1.12-23.49, p = 0.021; rs187238: OR = 4.99, 95% CI = 1.08–23.06, p = 0.025). Additionally, the “CC” genotype of rs1946519 was associated with increased risk of COPD (OR = 2.31; 95% CI = 1.03–5.19; p = 0.038). By contrast, the “TT” genotype of rs1946518 was associated with decreased risk of COPD (OR = 0.58; 95% CI = 0.35–0.98; p = 0.039). Our data shed new light on the association between IL18 polymorphisms and risk of COPD in a Chinese Han population.
Highlights
In recent years, with the developing of industry and worsening of air condition, more and more people suffer from chronic respiratory disease
The “TT” genotype of rs1946518 was associated with decreased risk of Chronic obstructive pulmonary disease (COPD) (OR = 0.58; 95% confidence intervals (CIs) = 0.35–0.98; p = 0.039)
Previous studies have identified several single nucleotide polymorphisms (SNPs) associated with COPD;, the results is still not enough to explain the heredity of COPD
Summary
With the developing of industry and worsening of air condition, more and more people suffer from chronic respiratory disease. COPD is distinguished by chronic airflow limitation, which mainly caused by local inflammation of the respiratory system and systemic inflammatory [1]. COPD is a complicated disease which influenced by multiple genes and interaction with environmental factors [3]. Previous literatures have identified several susceptibility genes contribute to the development of COPD, including SCGB1A1, CHRNA5, VEGF-A, FAM13A, SETD7 and so on [4,5,6]. This is not enough to explain the hereditary susceptibility of COPD. Researchers still concentrate on work on identifying more susceptibility genes for this disease
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