Abstract
This work is the first genetic association study of a potential relationship of single nucleotide polymorphisms rs8193036 and rs2275913 located in the IL17A promoter on chromosome 6p12 to chronic viral hepatitis and its progression in Kazakh population. Evaluation of the effect of IL17A polymorphism on predisposition for chronic hepatitis B and C and its progression to liver cirrhosis. A total of 862 individuals were enrolled in the retrospective case-control association study. Among the participants, 100 patients had chronic hepatitis B and/or C and liver cirrhosis, and 341 patients had chronic viral hepatitis only. Four hundred twenty-one (421) healthy HBV- and HCV-negative donors without liver diseases were recruited as population control. single nucleotide polymorphisms rs8193036[T/C] and rs2275913[G/A] were genotyped by TaqMan assays using genomic DNA extracted from peripheral blood cells. Results. Minor allele frequencies of rs8193036[C] and rs2275913[A] in the groups of patients were very similar to those observed in the control population, 0.4 and 0.3, respectively. Multivariate logistic regression analysis revealed odds ratios close to 1.0 and confidence intervals overlapping with the value of 1.0 and statistical significance p > 0.4 for any groups under comparison in the multiplicative model of inheritance. No significant association between two single nucleotide polymorphisms, rs8193036 and rs2275913 in the IL17A promoter, and susceptibility to chronic viral hepatitis C and/or B and disease progression to liver cirrhosis in Kazakh population were found.
Highlights
This work is the first genetic association study of a potential relationship of single nucleotide polymorphisms rs8193036 and rs2275913 located in the IL17A promoter on chromosome 6p12 to chronic viral hepatitis and its progression in Kazakh population
A total of 862 individuals were enrolled in the retrospective case-control association study
Four hundred twenty-one (421) healthy HBV- and HCV-negative donors without liver diseases were recruited as population control
Summary
Lo Y.M., Chan L.Y., Chan A.T. Leung S.F., Lo K.W., Zhang J. et al Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma. Shao J.Y., Zhang Y., Li Y.H. Gao H.Y., Feng H.X., Wu Q.L. et al Comparison of Epstein-Barr virus DNA level in plasma, peripheral blood cell and tumor tissue in nasopharyngeal carcinoma. Масабаева М.Р.1, Аукенов Н.Е.1, Мусажанова Ж.Б.2, Саенко В.А.2, Рогунович Т.И.2, Шаймарданов Н.К.1, Курманова Б.Р.1, Баркибаева Н.Р.1, Yamashita Shunichi, Рахыпбеков Т.К.1. С ХРОНИЧЕСКИМ ВИРУСНЫМ ГЕПАТИТОМ И ПРОГРЕССИРОВАНИЕМ к ЦИРРОЗу ПЕЧЕНИ В КАЗАХСКОЙ ПОПУЛЯЦИИ. Взаимосвязь двух исследованных однонуклеотидных полиморфизмов rs8193036 и rs2275913 в промоторе гена IL17A с предрасположенностью к заболеванию хроническим вирусным гепатитом В и/или С и его прогрессированием в цирроз печени в казахской популяции не выявлена. Для цитирования: Масабаева М.Р., Аукенов Н.Е., Мусажанова Ж.Б., Саенко В.А., Рогунович Т.И., Шаймарданов Н.К., Курманова Б.Р., Баркибаева Н.Р., Yamashita Shunichi, Рахыпбеков Т.К.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
