Abstract
BackgroundInterleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the IL17A and IL17F genes and RA.MethodsWe examined 422 RA patients and 337 subjects as a control group. Single nucleotide polymorphism (SNP) in the IL17A (rs2275913) and IL17F (rs763780, rs11465553, rs2397084) genes were genotyped using TaqMan genotyping assays from Life Technologies Genomic.ResultsThere were no significant differences in distribution of IL17A and IL17F genotypes and alleles between RA patients and control group. There were no significant associations between IL17A and IL17F genotypes and age of disease diagnosis rheumatoid factor, erosive disease as well as extra-articular manifestations.ConclusionsThe results of this study suggest, that IL17A and IL17F gene polymorphism are not the important factors associated with susceptibility and some clinical parameters of RA in a Polish population.
Highlights
Interleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA)
Interleukin-17A is significantly more potent than IL-17F, whereas the IL-17A/IL-17F heterodimer has intermediate activity [2]. Both IL-17A and IL-17F use the IL-17 receptor A (IL-17RA)-IL-17RC heterodimer for their signaling, IL-17A binds IL-17RA with much higher affinity [3]
There were no significant associations between IL17A and IL17F genotypes and age of disease diagnosis, rheumatoid factor, erosive disease as well as extra-articular manifestations (Table 2)
Summary
Interleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with the destruction of affected joints. Numerous cytokines play the important role in the RA pathogenesis, which initiate and maintenance the inflammatory response in joints. Interleukin-17A is one member of a cytokine family consisting of six cytokines: IL-17A, IL-17B, IL-17C, IL17D, IL-17E, and IL-17F. Both IL-17A and IL-17F are secreted by Th17 cells and other immune cells, including innate lymphoid cells [1]. Interleukin-17A is significantly more potent than IL-17F, whereas the IL-17A/IL-17F heterodimer has intermediate activity [2] Both IL-17A and IL-17F use the IL-17 receptor A (IL-17RA)-IL-17RC heterodimer for their signaling, IL-17A binds IL-17RA with much higher affinity [3]
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