Abstract
Early marginal bone loss around dental implants before stage II surgery occurs occasionally despite lack of obvious cause and etiology of this bone loss is not clear. Genetic polymorphisms that regulate the inflammatory process have been considered a genetic risk factor for early bone loss around implants. Interleukin-15 (IL-15) up-regulates pro-inflammatory cytokines such as TNF-α and IL-6 and enhances immunoglobulin secretion in the presence of oral bacteria lipopolysaccharides. In peri-implant tissues, those pathways may lead to bone resorption. IL-15 has potential role in bone remodeling, and resorption of bone around the hip implants. rs1057972 polymorphisms in the IL-15 gene have been associated with inflammatory and autoimmune diseases. The aim of this study was to investigate whether the IL-15 gene polymorphism is associated with early periimplant bone loss before stage-II surgery.
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