IL-12 und IL-18 als perioperative Risikoanalyse einer letalen Sepsis

Abstract

Postoperative sepsis after major visceral surgery is a severe complication with high mortality. The aim of the study was to find indicators which allow for a detection of high risk patients for septic compli-cations and early predictive parameters for a severe course of abdominal sepsis. The function of monocytes prior to surgery and its significance for postoperative sepsis was examined in 1113 patients. Monocytes from patients developing lethal postoperative sepsis exhibited an impaired secre-tion of IL-12 p70 and IL-12 p40. Preoperative monocyte IL-12 production was identified as a predic-tive factor for lethal outcome.