Abstract
The interleukin 11 (IL-11) receptor α chain complexes with a β chain, gpl30, to form a functional high-affinity receptor for IL-11.. This chapter presents a study in which mice with a null mutation of the Il11Ra1 gene appeared phenotypically normal. Examination of peripheral blood, bone marrow and spleen, CFU-S assays, and clonal cultures of hematopoietic progenitor cells did not identify any perturbation of hematopoiesis in these mice. The hematopoietic recovery after cytoablation and hemolysis was also normal. Unexpectedly, homozygous mutant females were infertile due to altered decidualization—the process of uterine stromal cell differentiation into specialized decidual cells in response to implantation. The results of this study indicate that IL-11 receptor signaling is not required for adult hematopoiesis.
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