Abstract
IL-11 in multiple sclerosis.
Highlights
The clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) is the first clinically evident phase of the disease
The studies of the inflammatory diseases have demonstrated that intra-articular injection of IL-11 causes joint inflammation, and that mSA/IL-1 acute arthritis was reduced in anti-IL-11 antibody-treated and IL-11Rα1-/mice [2]
IL-11 is produced by activated astrocytes and IL11Rα is expressed on oligodendrocytes in MS brain lesions
Summary
The clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) is the first clinically evident phase of the disease. STAT3, a transcription factor involved in Th17 cell differentiation, is predominantly activated in response to IL-6/IL-6R and IL-11/IL-11R axis. While IL-6 is generally accepted as the prototypical pro-inflammatory cytokine, the role of IL-11 in the autoimmune response is poorly understood.
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