IL-10 genetic polymorphisms were associated with valvular calcification in Han, Uygur and Kazak populations in Xinjiang, China.

Yong An,Dilare Adi,Yi-Tong Ma,Fen Liu,Muhuyati Wulasihan,Yong-Tao Wang,Xiao-Mei Li,Bang-Dang Chen,Xiang Xie,Ding Huang,Xiang Ma,Yi-Ning Yang,Ying Huang,Katherine Yutzey

doi:10.1371/journal.pone.0128965

Yong An, Dilare Adi + Show 12 more

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https://doi.org/10.1371/journal.pone.0128965

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Abstract

ObjectiveValvular calcification occurs via ongoing endothelial injury associated with inflammation. IL-10 is an anti-inflammatory cytokine and 75% of the variation in IL-10 production is genetically determined. However, the relationship between genetic polymorphisms of IL-10 and valvular calcification has not been studied. The objective of this study was to investigate the association between valvular calcification and IL-10 genetic polymorphisms in the Han, Uygur and Kazak populations in China.Patients and MethodsAll of the participants were selected from subjects participating in the Cardiovascular Risk Survey (CRS) study. The single nucleotide polymorphisms (SNPs) rs1800871 and rs1800872 of the IL-10 gene were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Three independent case-control studies involving the Han population, the Uygur population and the Kazak population were used in the analysis.ResultsFor the Han and Kazak populations, rs1800871 was found to be associated with valvular calcification in the recessive model, and the difference remained statistically significant following multivariate adjustment (p<0.001, p=0.031, respectively). For the Han, Uygur and Kazak populations, rs1800872 was found to be associated with valvular calcification in the dominant model, and the difference remained statistically significant following multivariate adjustment (p<0.001, p=0.009, and p=0.023,respectively)ConclusionBoth rs1800871 and rs1800872 of the IL-10 gene are associated with valvular calcification in the Han and Kazak populations in China. Rs1800872 is also associated with valvular calcification in the Uygur population.

Highlights

Valve calcification, that is aortic valve calcification or mitral annular calcification (MAC), is a common finding in elderly individuals [1]
For the Han and Kazak populations, rs1800871 was found to be associated with valvular calcification in the recessive model, and the difference remained statistically significant following multivariate adjustment (p
For the Han, Uygur and Kazak populations, rs1800872 was found to be associated with valvular calcification in the dominant model, and the difference remained statistically significant following multivariate adjustment (p

Summary

Introduction

That is aortic valve calcification or mitral annular calcification (MAC), is a common finding in elderly individuals [1]. Otto et al [4] demonstrated that the presence of aortic valve calcification was associated with an increase of approximately 50 percent for the risk of both death from cardiovascular (CV) causes and a new myocardial infarction. Additional studies have shown that aortic valve calcification and MAC are significantly associated with CV morbidity and mortality [6,7,8,9]. The inheritance of several susceptibility genes and multiple environmental determinants are thought to increase the risk for developing valvular calcification [10,11]. Many genes that are involved in the process of inflammation have been considered to be candidate genes for valvular calcification

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